Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
Highlights:
• Omicron spike stably maintains an active conformation for receptor recognition
• Improved stability of Omicron enhances attachment but compromises viral fusion
• Mutations perturb the conformation of antigenic sites recognized by most antibodies
• Structurally restrained regions of RBM can be targets for COVID-19 countermeasures
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